Biological structure of Lab-on-a-Chip nanosensors in DNA detection (based on PhD in nano-microelectronics)
Researcher and author: Dr. ( Afshin Rashid)
Note: The proliferation and proliferation of Lab-on-a-Chip diagnostic nanosensors in DNA detection is the more specialized function of nano-chips or gene and protein microarrays containing markers against the entire human genome to study genetic changes.
Gene and protein microarrays in very small sizes with the ability to make molecular detections based on DNA and human protein sequences and other pathogens used for research. With the proliferation of biological nanosensors and micronutrients Lab on a chip, medical diagnostic laboratories are able to study and measure hundreds of biological substances from blood cell counts to detailed examination of blood factors and other body fluids and tissues, pathology laboratories Clinically, a variety of imaging systems such as radiology, ultrasound, endoscopy, CT scan, MRI and other specialized diagnostic methods for the examination of various diseases such as angiography, echocardiography, ECG and other organs are highly developed. Is . With the development of human knowledge in the fields of cellular and molecular sciences, genetics and identification of genes causing various diseases, Determining the genome of pathogens, reviewing and comparing them and creating genomic databases, developing molecular diagnostic methods, specialized laboratories of these methods for accurate diagnosis of infectious pathogens, some genetic disorders and even in some cases for prenatal diagnoses And the possibility of the fetus being infected with severe inherited diseases and determining the sex of the fetus.
(Microarray technology) Microarray technology Gene and protein arrays Although several years have passed since the identification of the structure and determination of the complete sequence of the human genome and it has been determined that the human genome is composed of 3 billion new clotides and about 30,000 genes, but a major change in Hereditary diseases have not been solved and the causes of various human diseases have not been discovered due to the complexities in the human genetic structure and various factors affecting it. Because previously it was thought that a gene is responsible for an activity and experts studied the structure and function of individual genes and proteins separately, but now it has been determined that several genes are involved in some disorders and a number of processes in A disease or cell damage and Tissues are involved. The result is that a method must be devised to simultaneously study the sequence, diversity, genetic differences, structure and activity of tens, hundreds and thousands of genes of proteins simultaneously. Combining molecular, microelectronics, robotics, nanotechnology, polymer chemistry, and molecular fusion technologies, it has made it possible to produce hundreds and thousands of specific markers (probes) of different genes and proteins in very small amounts (nanoliters) using many needles. Fine on the surface of a microscopic glass slide in regular rows (arrays). In this way, by adding a sample containing healthy and sick Protein-RNA-DNA, it is possible to study genetic changes in different genes and proteins .
Author: Dr. ( Afshin Rashid)