Biological nanosensors and microscopic Lab on a chip diagnostic laboratories (PhD in nano-microelectronics)
Researcher and author: Dr. ( Afshin Rashid)
Note: The proliferation and proliferation of Lab-on-a-Chip diagnostic nanosensors in DNA detection is the more specialized function of nano-chips or gene and protein microarrays containing markers against the entire human genome to study genetic changes.
Gene and protein microarrays in very small sizes with the ability to make molecular detections based on DNA and human protein sequences and other pathogens used for research. By amplifying biological nanosensors and Lab on a chip microelements, medical diagnostic laboratories are able to study and measure hundreds of biological substances, from blood cell counts to detailed examination of blood factors and other body fluids and tissues. Pathological laboratories Clinically, various imaging systems such as radiology, ultrasound, endoscopy, CT scan, MRI and other specialized diagnostic methods for the examination of various diseases such as angiography, echocardiography, ECG and other organs are highly developed. Is . With the development of human knowledge in the fields of cellular and molecular sciences, genetics and identification of genes causing various diseases, Determining the genome of pathogens, examining and comparing them and creating genomic databases, developing molecular diagnostic methods, specialized laboratories of these methods for accurate diagnosis of infectious pathogens, some genetic disorders and in some cases for prenatal diagnoses And the possibility of the fetus being infected with severe inherited diseases and determining the sex of the fetus.
(Microarray technology) Technology Microarray Gene and protein arrays Although several years have passed since the identification of the structure and determination of the complete sequence of the human genome and it has been determined that the human genome is composed of 3 billion new clotides and about 30,000 genes. Hereditary diseases have not been solved and the causes of various human diseases have not been discovered due to the complexities in the human genetic structure and various factors affecting it. Because previously it was thought that a gene is responsible for an activity and experts studied the structure and function of individual genes and proteins separately, but now it has been determined that several genes are involved in some disorders and a number of processes in A disease or cell damage and Tissues are involved. The result is that a method must be devised to simultaneously study the sequence, diversity, genetic differences, structure, and activity of tens, hundreds, and thousands of genes of proteins simultaneously. Combining molecular technologies, microelectronics, robotics, nanotechnology, polymer chemistry, and molecular linkages , it has made it possible to have hundreds and thousands of specific markers (probes) of different genes and proteins in very small amounts (nanoliters) using many needles. Fine on the surface of a microscopic glass slide in regular rows (arrays). In this way, by adding a sample containing healthy and sick Protein-RNA-DNA, it is possible to study genetic changes in different genes and proteins .
Researcher and author: Dr. ( Afshin Rashid)
PhD in Nano-Microelectronics