Kinetics of self-assembly in electric nano-biosensors and self-assembled biomolecular nanostructures

_ Department of Nano Bioelectrical Laboratory (Nano Biosensors)

Kinetics of self-assembly in electric nano-biosensors and self-assembled biomolecular nanostructures 

Researcher  and author: Dr.   (   Afshin Rashid)

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Note: Within the particle structure of nano biosensors, the nanostructures are usually organized using local assembly rules that order;  They produce with a long range  .  Because these rules can take into account the structure and current state of the cell, they can assemble complexes, organelles, or skeletal structures around existing cellular components to form integrated architectures.

 Although many methods  have been developed to make self-assembled biomolecular nanostructures. A few can be designed to assemble structures whose shape depends on the identity and organization of structures already present in the environment.   DNA nanotubes can be grown to bind pairs of molecular markers with different separation distances and relative orientations.  DNA tile nanotubes form at these landmarks and grow as their free ends disperse.  The nanotubes can then join themselves to form stable, end-to-end junctions, and unconnected nanotubes can be selectively melted.  Junctions between labeled pairs are separated by more than 1 to 10 μm in more than 75% of cases and can form one surface or three dimensions.  This point-by-point assembly process demonstrates how the kinetics of self-assembly can be tailored to produce structures with desired properties rather than a specific shape.

Analyzer, sensor, converter and detector are the components of the nano sensor system and its feedback reaches the nano sensor from the detector.  Sensitivity, specificity and ease of implementation are the main goals in the design of a nanosensor. Nanosensors typically work by monitoring electrical changes in the sensing material.

For example, nanosensors based on carbon nanotubes work in this way.  When a molecule of nitrogen dioxide (NO  ₂  ) is present, it removes an electron from the nanotube, which in turn makes the nanotube less conductive. If ammonia (NO  ₃  ) is present, it reacts with water vapor and donates an electron to the carbon nanotube, making it conductive.  By treating nanotubes with different coating materials, they can be made sensitive to certain molecules and immune to others. Like chemical nanosensors, mechanical nanosensors also tend to measure electrical changes.

Conclusion : 

Within the particle structure of nanobiosensors, the nanostructures are usually organized using local assembly rules that order;  They produce with a long range  .  Because these rules can take into account the structure and current state of the cell, they can assemble complexes, organelles, or skeletal structures around existing cellular components to form integrated architectures.

Researcher  and author: Dr.   (   Afshin Rashid)

Specialized doctorate in nano-microelectronics